Overactive bladder

Overactive bladder is defined by the frequent and urgent need to urinate.

Overactive bladder affects around 25% of women and 20% of men.

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What is it?

Overactive bladder is defined by the frequent (pollakiuria) and urgent need to urinate. It occurs when the bladder muscles begin to contract involuntarily even when the volume of urine stored in the bladder is low.

People with overactive bladder may urinate more than 12 times a day or every half hour, and it's common for them to also need to get up frequently to use the bathroom at night (nocturia). This significantly impacts the quality of life of those affected, as it can limit their social and professional lives.

This condition affects around 25% of women and 20% of men. Even so, many cases go undiagnosed because those who have it don't consider it important, think it's normal, or are embarrassed to see a specialist.

To combat the symptoms, those who suffer from it can begin by trying some lifestyle changes, such as dietary modifications, timed voiding strategies, or bladder control techniques using the pelvic floor muscles. Likewise, maintaining a healthy lifestyle can help reduce the risk of developing an overactive bladder.

  • Keep a healthy weight.
  • Engage in daily physical activity and exercise.
  • Reduce the consumption of caffeine and alcohol.
  • Give up smoking.
  • Control chronic conditions, such as diabetes, which can exacerbate overactive bladder symptoms.
  • Strengthen your pelvic floor with exercises like Kegels. Some of these exercises involve tensing or contracting the muscles, holding the contraction for two seconds, and then relaxing the muscles for three seconds. Gradually increase the time until you can hold the contraction for five seconds, and then for ten seconds. Do three sets of ten repetitions a day.

If these guidelines do not help enough, a doctor can evaluate whether there is a specific cause and prescribe the appropriate treatment.

The main symptoms of overactive bladder are:

  • Sudden urge to urinate and a strong need to do so immediately.
  • Frequent urination, generally eight or more times a day or more than twice at night (nocturia).
  • Experiencing urinary incontinence associated with urgency.
  • Reduction in the amount of urine.

These symptoms can affect a person's quality of life, sometimes even triggering:

  • Emotional suffering.
  • Anxiety.
  • Sleep disturbances or disruption of sleep cycles.
  • Problems with sexuality.
  • It affects social and work life.

On the other hand, if you experience an involuntary loss of urine immediately after an urgent need to urinate, we are talking about urge incontinence.

IMPORTANT: Several conditions can present symptoms similar to those of overactive bladder, such as urinary tract infections, prostate disease, or bladder tumors, among others. Therefore, it is important to rule out any other illness before correctly diagnosing overactive bladder.

When the bladder fills, nerve signals are sent to the brain, triggering the urge to urinate. During urination, these signals coordinate the relaxation of the pelvic floor muscles: the bladder muscles contract to expel the urine, and the urethral sphincter opens to allow the urine to flow out. This urge to urinate in humans is triggered by social situations where we can urinate. This is why we can hold our urine.

From a urodynamic perspective, overactive bladder occurs when the bladder muscles (detrusor) begin to contract involuntarily even when the volume of urine stored in the bladder is low. These involuntary contractions create an urgent need to urinate.

The cause of overactive bladder is not always known, but there are multiple factors that can contribute to the presence of compatible symptoms:

  • High intake of fluids, caffeine, or alcohol
  • Neurological disorders such as spinal cord injuries, multiple sclerosis, Parkinson's disease, Alzheimer's, or strokes.
  • Infection in the urinary tract.
  • Urethral obstruction due to enlarged prostate, constipation, or previous surgery.
  • Bladder abnormalities, such as tumors or stones
  • Diabetes
  • Hormonal changes during menopause in women
  • Medications that cause a rapid increase in urine production or that must be taken with plenty of fluids.
  • Age-related cognitive decline, which can prevent the bladder from correctly interpreting signals sent by the brain.
  • Incomplete bladder emptying, which can cause overactive bladder symptoms as there is little space left to store urine.

Overactive bladder is characterized by urinary urgency—with or without urinary incontinence—associated with increased daytime and nighttime urination frequency. For diagnosis, the physician must document all the patient's symptoms and signs and rule out other conditions that could be causing them.

The initial evaluation of patients with overactive bladder should include:

Clinic history:

It is essential in the initial assessment and should record the type, duration, and severity of symptoms, as well as the presence or absence of urinary incontinence. Furthermore, it should allow for differentiation between urge urinary incontinence, stress urinary incontinence, and mixed urinary incontinence.

It is important to describe symptoms clearly and avoid ambiguous terms to prevent confusion. For example, you should record daytime urination frequency, time between urinations, nighttime urination frequency, and the number of times you get up to urinate at night.

Likewise, the medical history should include any pathology that the patient may present, as well as the pharmacological treatments he receives to check if they may have any impact on the symptoms of overactive bladder or cause them.

On the other hand, any symptoms and/or history that might suggest the need for referral for further evaluation should be identified. If lower abdominal or perineal pain is present before, during, or after urination, the patient should not be diagnosed with overactive bladder syndrome.

Physical exploration:

It includes abdominal examination to detect increased bladder volume or the presence of other abdominal masses.
In men, a digital rectal examination should be performed, and in women, estrogen status and the possible presence of prolapse (descent of the pelvic organs due to weakening of the pelvic floor) should be evaluated.

Urine analysis:

This test is performed to rule out urinary tract infection or hematuria. Urine sediment analysis is necessary to ensure there is no underlying organic abnormality in the bladder causing the symptoms: urinary tract infection, hematuria, leukocyturia, or suspected bladder stones.

Voiding diary:

Voiding diaries are a reliable tool for measuring urine volume, urinary frequency, and episodes of urinary urgency and incontinence. They are also useful for monitoring progress and outcomes after treatment.

Questionnaires:

Based on validated Spanish-language symptom scoring scales and questionnaires that have proven useful for measuring changes in patients' conditions, this tool allows for measuring symptom severity, screening or classifying urinary incontinence if present, and helping to determine if a change in treatment is needed.

On the other hand, the impact of overactive bladder symptoms on quality of life is an important aspect in its management.

Other evidence:

  • Determination of post-void residualIt is not necessary in patients without complications, but in those who have symptoms of incomplete bladder emptying, complicated urinary incontinence, or who are receiving treatments that could cause or worsen emptying symptoms.
  • FlowmetryDue to the high incidence of increased prostate size in men over 50 years of age, which can affect bladder emptying, uroflowmetry is recommended.
  • UrodynamicsIt will be performed in cases of incontinence, when there is no response to the initial treatment, when there has been previous surgery in the lower urinary tract, or when there is a neurogenic disease.
  • Cystoscopy and diagnostic imaging: will be performed in case there is a pathological sediment and there is a suspicion of organic involvement of the bladder.

Behavior modification

As a first step in treating overactive bladder, it is recommended to implement a behavior modification program that includes hygiene and dietary guidelines.

These treatments can be adapted to the needs and abilities of the patients. In most cases they are effective and not associated with adverse effects, but active patient participation is necessary.

  • Body weight control To achieve and maintain a healthy weight: weight loss can relieve overactive bladder symptoms and help you manage urinary incontinence if you have it.
  • Control of fluid intakeControlled fluid intake reduction can decrease the frequency and urgency associated with overactive bladder. It is recommended that the causes of high fluid intake be investigated in the patient's medical history, keeping in mind that fluid restriction can produce undesirable effects such as urinary tract infection, dehydration, or constipation.
  • Reduction in caffeine consumption.
  • Treatment of constipation In adults, if necessary. It is advisable in cases of urinary incontinence.
  • Quitting smoking.
  • Scheduled voiding guidelinesEstablish a schedule for going to the bathroom, for example, every two to four hours, to get used to urinating at the same times every day instead of waiting until you feel an urgent need to urinate.
  • Bladder trainingBladder training involves controlling the urge to urinate when you feel the need. You should start by holding your urine for short periods (2-5 minutes from the moment the urge arises) and gradually increase the time, aiming to urinate every two hours. This is only possible if you can properly tighten (contract) your pelvic floor muscles.
  • Kegel exercises to strengthen muscles of the pelvic floor and urinary sphincter. Strengthening these muscles helps to stop involuntary bladder contractions. The benefits of these exercises will depend on how regularly you perform them.

If necessary, the above guidelines can be combined with pharmacological treatment.

Pharmaceutical products

Bladder relaxant medications can be helpful in relieving overactive bladder symptoms and reducing episodes of urge urinary incontinence: mirabegron, vibegron, solifenacin, fesoterodine, desfesoterodine, tolterodine, oxybutynin, trospium.

These medications can have side effects such as dry eyes and mouth (drinking water to quench thirst can worsen overactive bladder symptoms) or constipation (which can worsen bladder symptoms). Extended-release forms of these medications, such as skin patches or gels, may have fewer side effects.

Your doctor may recommend sipping small amounts of water, sucking on a sugar-free candy, or chewing sugar-free gum to relieve dry mouth, as well as using eye drops to keep your eyes moist. To prevent constipation, your doctor may recommend a high-fiber diet or stool softeners.

On the other hand, women going through menopause may be prescribed vaginal estrogens, usually applied topically, to help strengthen the muscles and tissues of the urethra and vaginal area, significantly improving the symptoms of overactive bladder.

Onabotulinum toxin type A injections

Onabotulinum toxin type A, also known as "Botox," is a protein produced by the bacteria that cause botulism. This protein is used in small doses injected directly into the bladder tissue to relax the muscles.

The effects typically last six months or more, requiring repeated injections. Side effects can include urinary tract infections and urinary retention. If you are considering Botox treatment, you must be able to catheterize yourself and be prepared to do so if urinary retention occurs.

Nerve stimulation

In cases that do not respond to other treatments, nerve modulation may be considered. This includes percutaneous stimulation of the posterior tibial nerve. A thin needle is inserted through the skin near the ankle to send electrical stimulation from a nerve in the leg (tibial nerve) to the spinal cord, where it connects with the nerves that control the bladder. Another alternative is the placement of a sacral nerve root neuromodulator.

Bladder enlargement

When previous treatments have been ineffective, the definitive treatment is bladder augmentation using small bowel tissue. Currently, this procedure is performed using minimally invasive robotic surgery.

FAQ

Overactive bladder, unlike stress urinary incontinence, does not have such a marked age component, so it also appears in young people.
Overactive bladder is related to involuntary contractions of the bladder muscle, so rehabilitation exercises are focused on the bladder.
Men also experience symptoms of overactive bladder and specific treatment should be considered for this.
In addition to lifestyle and dietary changes, there are specific oral medications and patches available for treating overactive bladder. Botulinum toxin injections are also a useful treatment for overactive bladder.
In cases of pelvic floor weakness and stress incontinence, surgery is performed to treat stress urinary incontinence. However, there is no clear surgical treatment for overactive bladder.
Patients with overactive bladder show detrusor muscle contractions during filling on urodynamic studies, which allows for the diagnosis of overactive bladder. In addition, urodynamic studies provide information on bladder capacity, bladder elasticity, bladder emptying function, and the presence of stress urinary incontinence, among other factors.

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