Kidney cancer usually does not produce symptoms in its initial stage.
When tumor growth has already occurred and is in more advanced stages, the most common symptoms are pain, appearance of abdominal mass and blood in the urine (hematuria).
Kidney cancer usually has no symptoms at an early stage of the disease. For this reason, most kidney tumors are diagnosed incidentally in the course of diagnostic tests performed for another reason when the tumor has not yet caused any symptoms. When there is tumor growth and the disease is at a more advanced stage it may present with a number of symptoms:
Scientists continue to investigate the factors that cause kidney cancer and ways to prevent it. Studies conducted so far conclude that there is a relationship between kidney cancer and the following factors:
To know if a kidney cyst is malignant, it is important to perform a series of studies and medical evaluations. The most common steps to determine the nature of a kidney cyst are: Renal ultrasound: ultrasound can show the shape and size of the cyst, as well as the presence of any suspicious features, such as irregular walls or inhomogeneous fluid. Computed tomography (CT): If the cyst has suspicious features on ultrasound, a CT scan may be done to obtain more detailed images. This helps to identify if there are solid masses within the cyst or changes in the cyst walls that suggest malignancy. Magnetic resonance imaging (MRI): is useful to better characterize the cyst and may provide additional information about its composition. This is particularly useful if there is doubt after the CT scan. Bosniak classification: The Bosniak classification system is used to categorize renal cysts based on their appearance on imaging and help determine the risk of malignancy. Biopsy: In some cases, if the cyst is suspected to be malignant or if imaging tests are inconclusive, a renal biopsy may be performed to obtain a sample of the tissue and examine it under the microscope. In general, benign kidney cysts do not cause symptoms. However, if a cyst becomes large, it may cause pain in the back or abdomen. If the cyst is malignant, there may be additional symptoms such as blood in the urine, unexplained weight loss or fatigue.
In general, in patients with renal tumors under 4 cm that are treated surgically, cure rates of over 90% are achieved. If the mass is large and has spread outside the kidney, the prognosis is worse, especially if any of the following factors are present: anemia, high lactate dehydrogenase level, high blood calcium level, spread to two or more distant sites, or if the person's general condition is unfavorable.
Kidney cancer is curable in early stages. It is key that, once kidney cancer is treated, the patient is followed closely. In advanced stages of the tumor, surgery can help palliate symptoms and, in selected patients, can be combined with other treatments such as chemotherapy or immunotherapy to improve survival and quality of life.
Surgery is the standard treatment, achieving cure rates of over 90% in small tumors. There are various types of surgery depending on the size of the tumor, but whenever possible, the aim is to remove only the tumor, preserving the rest of the kidney and renal function.
Impact of Metastasectomy on Cancer Specific and Overall Survival in Metastatic Renal Cell Carcinoma: Analysis of the REMARCC Registry.